Cancer [CNK]-English

Cancer [CNK]

Where are they?

Blood
Skin
Intestine
Liver
Feathers
Uterus

How do they work?

Decrease in the expression of HLA
Receptor signals
To differentiate NK cells, membrane receptors can be analyzed
The proteins that can be found on their membrane are CD16 and CD56

Cytotoxic function

They act on tumor cells, virus-transformed cells, and cells infected with bacteria and other pathogens.

Recognition of target cells
Contact with target cells and the formation of an immunological synapse
Death of the target cell induced by NK cells

Cytokine secretion function

The ability to secrete various types of cytokines Regulatory proteins, tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ) Granulocyte-macrophage colony-stimulating factor (GM-CSF) Proliferation, differentiation, and activation of the immune response

Antitumor function

NK cells:

Detecting cells that have undergone malignant transformation

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