Cancer [CNK]

Where are they?

  • Blood
  • Skin
  • Intestine
  • Liver
  • Feathers
  • Uterus

How do they work?

  • Decrease in the expression of HLA
  • Receptor signals
  • To differentiate NK cells, membrane receptors can be analyzed
  • The proteins that can be found on their membrane are CD16 and CD56

Cytotoxic function

They act on tumor cells, virus-transformed cells, and cells infected with bacteria and other pathogens.
  • Recognition of target cells
  • Contact with target cells and the formation of an immunological synapse
  • Death of the target cell induced by NK cells

Cytokine secretion function

The ability to secrete various types of cytokines Regulatory proteins, tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ) Granulocyte-macrophage colony-stimulating factor (GM-CSF) Proliferation, differentiation, and activation of the immune response

Antitumor function

NK cells:

  • Detecting cells that have undergone malignant transformation

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